Uses of Misoprostol in therapeutic abortion

Uses of Misoprostol in therapeutic abortion

Misoprostol. Its use in therapeutic abortion

Around the world, millions of women have risked their lives and health to end an unwanted pregnancy, using abortion, which is as old as mankind. This procedure, which almost all women in the New and Old Worlds have undergone, is not without risk.
It is estimated that more than 55 000 unsafe abortions take place every day, 95% of them in developing countries, which leads to a high rate of maternal morbidity and mortality. The World Health Organization (WHO) estimates that globally one in eight maternal deaths are due to abortion-related complications.

Perhaps no other health issue has been more controversial than abortion. In 1984, the most problematic issue at the International Conference on Coagulation, held in Mexico, was the situation of abortion in family planning. According to a WHO publication, in developed countries where abortion is legal and practiced within the health system, maternal mortality is lower (one death for every 100,000 abortions performed). In contrast, in developing countries where abortion is legally restricted, mortality is estimated to be between 100 and 1 000 deaths per 100 000 procedures.

At the International Conference on Population and Development in Cairo, sponsored by the United Nations in 1994 and the Fourth Women’s Conference

The 1995 Beijing Conference reaffirmed women’s rights In that conference, it was agreed that the rights the rights of women and men in the field of reproductive health encompass certain human rights that are recognized by international laws and documents. This right, considered basic to every The right of all couples and individuals to decide freely and responsibly on the number and spacing of their children and to have access to the information and means to do so is the right to the highest standard of sexual and reproductive health.

Abortion, in Latin America, is more critical because it is not legalized. However, currently, in many countries in Europe, Asia, Latin America, and a growing number of Third World countries, medications to interrupt a pregnancy are used as alternative methods for uterine evacuation by physical means (curettage and aspiration). Health personnel needs to be aware of the current relevance of abortion drugs in many countries and, based on scientific evidence, for health personnel to consider and define the potential value of these drugs for use in the region.

In the face of the illegality of abortion in many countries, women have adopted a two-fold strategy: to initiate it by performing some abortive maneuvers themselves
or by calling in a third party and then going to the hospital for the termination of the contract.
The problem of incomplete abortion is one of high morbidity and mortality.

Medical abortion has revolutionized as a new technique for termination of unwanted pregnancy, using appropriate routes that do not require the woman’s hospitalization is usually uncomplicated and the side effects are minor. Recently, it has been used worldwide for this abortion. In April 1980 Georges Teutsch and Daniel Philibert, from the Roussel Uclaf laboratories and the scientist Frances Etienne-Emile Bauleiu, succeeded in synthesizing RU-486, a steroid that is currently commercially registered as Mifegyne (Mifepristone). In October 1981
the first study was carried out on 11 women in Switzerland; it resulted in the interruption of pregnancies, but adverse reactions were detected by affecting the adrenal glands. To eradicate these negative results, this was combined with prostaglandin. Since 1970 it has been known that prostaglandins induce contractions have been used throughout the world to start the process of childbirth and to terminate the pregnancy.

One of the most commonly used drugs in medical abortion is the misoprostol, which is a synthetic analogue of PGE-1, marketed in 72 countries for the prevention and treatment of gastroduodenal ulcer that like other prostaglandins has a strong utero-contractive action. Misoprostol by the vaginal route has proven to be effective as a pharmacological abortifacient
and is very useful when used with methotrexate IM and Mifepristone for early abortion. It is suggested that of all the women who have used this method, 92% to 96% have had a complete abortion.

Misoprostol is a pharmacological abortifacient creates the force of contraction the uterine lining facilitates the detachment and subsequent expulsion of the gestational sac.Its effectiveness may be directly related to the amount of misoprostol to be absorbed into the bloodstream; therefore, it is necessary to consider the hypothesis that by administering the dose of misoprostol at shorter intervals would cause stronger and more sustained contractions that are more capable of releasing the fertilized egg from the endometrium.

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